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Detailed information for vg0822982462:

Variant ID: vg0822982462 (JBrowse)Variation Type: SNP
Chromosome: chr08Position: 22982462
Reference Allele: TAlternative Allele: G
Primary Allele: GSecondary Allele: T

Inferred Ancestral Allele : T (evidence from allele frequency in Oryza rufipogon: T: 0.93, G: 0.07, others allele: 0.00, population size: 209. )

Flanking Sequence (100 bp) in Reference Genome:


CAAGCTAGACACCAATGAAGCTGCTAATATCCAGCCTTGATTCGTCAAGAGCCACTAGAGTCGAGCTTCCATACATACAAGTGATACAACCACCACCTCG[T/G]
CAGACCTAATGAGACTAGTAAATAGGTATAGGGTAGACACATATACACTTTTATACTCGTGTTATACATATATCAACAAAACAATAGGCCTATATATACC

Reverse complement sequence

GGTATATATAGGCCTATTGTTTTGTTGATATATGTATAACACGAGTATAAAAGTGTATATGTGTCTACCCTATACCTATTTACTAGTCTCATTAGGTCTG[A/C]
CGAGGTGGTGGTTGTATCACTTGTATGTATGGAAGCTCGACTCTAGTGGCTCTTGACGAATCAAGGCTGGATATTAGCAGCTTCATTGGTGTCTAGCTTG

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of T(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 64.60% 35.00% 0.08% 0.30% NA
All Indica  2759 98.50% 1.20% 0.07% 0.22% NA
All Japonica  1512 1.60% 98.10% 0.00% 0.33% NA
Aus  269 64.70% 35.30% 0.00% 0.00% NA
Indica I  595 99.70% 0.00% 0.17% 0.17% NA
Indica II  465 98.50% 1.10% 0.00% 0.43% NA
Indica III  913 99.50% 0.40% 0.00% 0.11% NA
Indica Intermediate  786 96.40% 3.20% 0.13% 0.25% NA
Temperate Japonica  767 1.80% 98.00% 0.00% 0.13% NA
Tropical Japonica  504 0.80% 98.80% 0.00% 0.40% NA
Japonica Intermediate  241 2.50% 96.70% 0.00% 0.83% NA
VI/Aromatic  96 90.60% 9.40% 0.00% 0.00% NA
Intermediate  90 58.90% 35.60% 2.22% 3.33% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0822982462 T -> G LOC_Os08g36410.1 upstream_gene_variant ; 909.0bp to feature; MODIFIER silent_mutation Average:79.714; most accessible tissue: Callus, score: 95.053 N N N N
vg0822982462 T -> G LOC_Os08g36420.1 downstream_gene_variant ; 4632.0bp to feature; MODIFIER silent_mutation Average:79.714; most accessible tissue: Callus, score: 95.053 N N N N
vg0822982462 T -> G LOC_Os08g36420.2 downstream_gene_variant ; 4632.0bp to feature; MODIFIER silent_mutation Average:79.714; most accessible tissue: Callus, score: 95.053 N N N N
vg0822982462 T -> G LOC_Os08g36390-LOC_Os08g36410 intergenic_region ; MODIFIER silent_mutation Average:79.714; most accessible tissue: Callus, score: 95.053 N N N N
vg0822982462 T -> DEL N N silent_mutation Average:79.714; most accessible tissue: Callus, score: 95.053 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0822982462 T G -0.06 -0.02 -0.02 0.0 0.01 0.02

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0822982462 NA 2.16E-31 mr1243 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 2.74E-17 mr1253 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 4.01E-48 mr1519 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 3.31E-25 mr1537 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 2.36E-06 7.70E-50 mr1591 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 8.14E-57 mr1594 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 8.54E-50 mr1599 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 8.04E-16 mr1700 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 2.39E-06 mr1761 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 1.67E-35 mr1828 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 2.41E-35 mr1223_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 4.09E-21 mr1298_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 1.81E-06 mr1488_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 6.99E-10 mr1506_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 1.88E-15 mr1578_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 5.23E-12 mr1666_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 3.39E-21 mr1698_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 1.62E-19 mr1731_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 4.70E-07 mr1824_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0822982462 NA 2.83E-13 mr1838_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251