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Detailed information for vg0519440425:

Variant ID: vg0519440425 (JBrowse)	Variation Type: SNP
Chromosome: chr05	Position: 19440425
Reference Allele: G	Alternative Allele: A
Primary Allele: G	Secondary Allele: A

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

TTGCTCTTGCTGATATGCAAGCGAGTAATACTCTCTCCGTCCCAAAATAAGTACAGTTTTAGCACTATTTATATCCAATATTTGACCGTTCGTCTTATTT[G/A]
AAAAAAGATTATGATTAGTATTTTTATTGTTATTAGATGATAAAACATGAATAGTACTTTATATGTGACTAATTTGTTTAATATTTTCTATAAATTTTTC

Reverse complement sequence

GAAAAATTTATAGAAAATATTAAACAAATTAGTCACATATAAAGTACTATTCATGTTTTATCATCTAATAACAATAAAAATACTAATCATAATCTTTTTT[C/T]
AAATAAGACGAACGGTCAAATATTGGATATAAATAGTGCTAAAACTGTACTTATTTTGGGACGGAGAGAGTATTACTCGCTTGCATATCAGCAAGAGCAA

Allele Frequencies:

Populations	Population Size	Frequency of G(primary allele)	Frequency of A(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	68.80%	23.10%	0.80%	7.28%	NA
All Indica	2759	51.60%	36.20%	1.09%	11.13%	NA
All Japonica	1512	96.40%	2.60%	0.40%	0.60%	NA
Aus	269	80.30%	11.20%	0.37%	8.18%	NA
Indica I	595	74.30%	18.50%	0.50%	6.72%	NA
Indica II	465	44.30%	44.10%	2.37%	9.25%	NA
Indica III	913	47.10%	36.60%	0.88%	15.44%	NA
Indica Intermediate	786	43.90%	44.50%	1.02%	10.56%	NA
Temperate Japonica	767	95.40%	3.10%	0.65%	0.78%	NA
Tropical Japonica	504	99.20%	0.80%	0.00%	0.00%	NA
Japonica Intermediate	241	93.80%	4.60%	0.41%	1.24%	NA
VI/Aromatic	96	99.00%	1.00%	0.00%	0.00%	NA
Intermediate	90	64.40%	27.80%	1.11%	6.67%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0519440425	G -> DEL	N	N	silent_mutation	Average:61.731; most accessible tissue: Callus, score: 90.983	N	N	N	N
vg0519440425	G -> A	LOC_Os05g33140.1	downstream_gene_variant ; 3691.0bp to feature; MODIFIER	silent_mutation	Average:61.731; most accessible tissue: Callus, score: 90.983	N	N	N	N
vg0519440425	G -> A	LOC_Os05g33140-LOC_Os05g33150	intergenic_region ; MODIFIER	silent_mutation	Average:61.731; most accessible tissue: Callus, score: 90.983	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0519440425	G	A	0.08	0.03	0.01	0.06	0.06	0.06

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0519440425	NA	4.20E-06	mr1632	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0519440425	NA	1.35E-06	mr1715	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0519440425	NA	4.96E-06	mr1740	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0519440425	NA	9.14E-06	mr1264_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0519440425	NA	2.47E-07	mr1517_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251