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Detailed information for vg0501506459:

Variant ID: vg0501506459 (JBrowse)Variation Type: SNP
Chromosome: chr05Position: 1506459
Reference Allele: GAlternative Allele: A
Primary Allele: GSecondary Allele: A

Inferred Ancestral Allele : G (evidence from allele frequency in Oryza rufipogon: G: 1.00, others allele: 0.00, population size: 322. )

Flanking Sequence (100 bp) in Reference Genome:


ATCAATGCAGATCCAAGGACAATGTAAGTATTGTTGAGGGCATTTCAATTTATGTGGTAAATTGGTAGCACAGCTATAACAAAATGCAATTGTGCAGCAC[G/A]
AACATGATATTCAAAGCAGAAACTCTTTTTCTGTATAGTATCTACTGTCTTCAACAAATAATCGCGAATAGTGTTTCCTACACATTGGCTCTAATATCCC

Reverse complement sequence

GGGATATTAGAGCCAATGTGTAGGAAACACTATTCGCGATTATTTGTTGAAGACAGTAGATACTATACAGAAAAAGAGTTTCTGCTTTGAATATCATGTT[C/T]
GTGCTGCACAATTGCATTTTGTTATAGCTGTGCTACCAATTTACCACATAAATTGAAATGCCCTCAACAATACTTACATTGTCCTTGGATCTGCATTGAT

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of A(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 89.70% 10.10% 0.30% 0.00% NA
All Indica  2759 96.10% 3.80% 0.07% 0.00% NA
All Japonica  1512 75.40% 23.80% 0.79% 0.00% NA
Aus  269 100.00% 0.00% 0.00% 0.00% NA
Indica I  595 100.00% 0.00% 0.00% 0.00% NA
Indica II  465 98.90% 1.10% 0.00% 0.00% NA
Indica III  913 90.10% 9.60% 0.22% 0.00% NA
Indica Intermediate  786 98.50% 1.50% 0.00% 0.00% NA
Temperate Japonica  767 97.10% 2.90% 0.00% 0.00% NA
Tropical Japonica  504 41.30% 56.70% 1.98% 0.00% NA
Japonica Intermediate  241 77.60% 21.60% 0.83% 0.00% NA
VI/Aromatic  96 100.00% 0.00% 0.00% 0.00% NA
Intermediate  90 88.90% 11.10% 0.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0501506459 G -> A LOC_Os05g03560.1 upstream_gene_variant ; 4590.0bp to feature; MODIFIER silent_mutation Average:59.077; most accessible tissue: Callus, score: 85.688 N N N N
vg0501506459 G -> A LOC_Os05g03550.1 intron_variant ; MODIFIER silent_mutation Average:59.077; most accessible tissue: Callus, score: 85.688 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0501506459 G A 0.0 0.0 0.0 0.0 0.0 0.0

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0501506459 NA 8.09E-07 mr1156 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0501506459 NA 4.68E-06 mr1179 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0501506459 NA 2.55E-07 mr1248 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0501506459 NA 9.91E-08 mr1668 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0501506459 3.24E-07 9.11E-31 mr1699 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0501506459 NA 4.06E-16 mr1699 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0501506459 NA 2.22E-07 mr1733 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251