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Detailed information for vg0410386441:

Variant ID: vg0410386441 (JBrowse)	Variation Type: SNP
Chromosome: chr04	Position: 10386441
Reference Allele: A	Alternative Allele: G
Primary Allele: A	Secondary Allele: G

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

GGTACACCAAAAGTTGATACAAATCAGAGTTTAACAAGCGGAAGCGTAAATAGAATTATTACACGGGCAACGAAGGCCCAGCACACTCAAAGACAACGAA[A/G]
AACAGCGGAAGACTAGGGCGAAGACCACAGGCACTTGACGGCAGGCACGAGCTAGACACCAAAGCCTTCATCTTCAGGGAACTCCTCATCTGGGCTTGGG

Reverse complement sequence

CCCAAGCCCAGATGAGGAGTTCCCTGAAGATGAAGGCTTTGGTGTCTAGCTCGTGCCTGCCGTCAAGTGCCTGTGGTCTTCGCCCTAGTCTTCCGCTGTT[T/C]
TTCGTTGTCTTTGAGTGTGCTGGGCCTTCGTTGCCCGTGTAATAATTCTATTTACGCTTCCGCTTGTTAAACTCTGATTTGTATCAACTTTTGGTGTACC

Allele Frequencies:

Populations	Population Size	Frequency of A(primary allele)	Frequency of G(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	41.50%	0.30%	9.94%	48.20%	NA
All Indica	2759	29.20%	0.50%	9.57%	60.64%	NA
All Japonica	1512	62.20%	0.10%	11.31%	26.39%	NA
Aus	269	50.20%	0.00%	5.95%	43.87%	NA
Indica I	595	15.80%	0.00%	6.05%	78.15%	NA
Indica II	465	25.20%	2.40%	14.62%	57.85%	NA
Indica III	913	38.70%	0.00%	10.19%	51.15%	NA
Indica Intermediate	786	30.90%	0.50%	8.52%	60.05%	NA
Temperate Japonica	767	96.20%	0.00%	0.13%	3.65%	NA
Tropical Japonica	504	6.50%	0.00%	29.76%	63.69%	NA
Japonica Intermediate	241	70.50%	0.40%	8.30%	20.75%	NA
VI/Aromatic	96	40.60%	0.00%	8.33%	51.04%	NA
Intermediate	90	44.40%	0.00%	12.22%	43.33%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0410386441	A -> DEL	N	N	silent_mutation	Average:64.852; most accessible tissue: Minghui63 young leaf, score: 94.549	N	N	N	N
vg0410386441	A -> G	LOC_Os04g18720.1	upstream_gene_variant ; 2044.0bp to feature; MODIFIER	silent_mutation	Average:64.852; most accessible tissue: Minghui63 young leaf, score: 94.549	N	N	N	N
vg0410386441	A -> G	LOC_Os04g18730.1	upstream_gene_variant ; 1905.0bp to feature; MODIFIER	silent_mutation	Average:64.852; most accessible tissue: Minghui63 young leaf, score: 94.549	N	N	N	N
vg0410386441	A -> G	LOC_Os04g18720-LOC_Os04g18730	intergenic_region ; MODIFIER	silent_mutation	Average:64.852; most accessible tissue: Minghui63 young leaf, score: 94.549	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0410386441	A	G	0.01	0.01	0.01	0.01	0.01	0.01

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0410386441	NA	2.02E-06	mr1130	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0410386441	NA	3.16E-06	mr1254	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0410386441	9.23E-08	9.23E-08	mr1926	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251