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Detailed information for vg0223522667:

Variant ID: vg0223522667 (JBrowse)	Variation Type: SNP
Chromosome: chr02	Position: 23522667
Reference Allele: G	Alternative Allele: T
Primary Allele: G	Secondary Allele: T

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

GGAAAACATTTTGGCCGAGGAGTGAAGGAGAGGACAAGCTTGAGAGACAGGACATTGGGAGTCGGAGAGGAGCACTTGCTTTCCCTCAAATCAACATAGC[G/T]
ATAAATATGGGGAACTCCAAAACATGTGCAAGGCTAGGGATCATTGGATCCGATTTTTCACCTAAAAGCCCTCAAAATCAGATTTGGGAAGAATATAAGA

Reverse complement sequence

TCTTATATTCTTCCCAAATCTGATTTTGAGGGCTTTTAGGTGAAAAATCGGATCCAATGATCCCTAGCCTTGCACATGTTTTGGAGTTCCCCATATTTAT[C/A]
GCTATGTTGATTTGAGGGAAAGCAAGTGCTCCTCTCCGACTCCCAATGTCCTGTCTCTCAAGCTTGTCCTCTCCTTCACTCCTCGGCCAAAATGTTTTCC

Allele Frequencies:

Populations	Population Size	Frequency of G(primary allele)	Frequency of T(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	94.30%	5.00%	0.15%	0.61%	NA
All Indica	2759	91.40%	8.40%	0.14%	0.04%	NA
All Japonica	1512	99.70%	0.10%	0.00%	0.20%	NA
Aus	269	100.00%	0.00%	0.00%	0.00%	NA
Indica I	595	88.90%	10.90%	0.17%	0.00%	NA
Indica II	465	98.90%	0.90%	0.00%	0.22%	NA
Indica III	913	87.40%	12.30%	0.33%	0.00%	NA
Indica Intermediate	786	93.40%	6.60%	0.00%	0.00%	NA
Temperate Japonica	767	99.90%	0.10%	0.00%	0.00%	NA
Tropical Japonica	504	99.80%	0.20%	0.00%	0.00%	NA
Japonica Intermediate	241	98.80%	0.00%	0.00%	1.24%	NA
VI/Aromatic	96	76.00%	0.00%	2.08%	21.88%	NA
Intermediate	90	94.40%	0.00%	1.11%	4.44%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0223522667	G -> T	LOC_Os02g38910.1	upstream_gene_variant ; 2116.0bp to feature; MODIFIER	silent_mutation	Average:75.739; most accessible tissue: Minghui63 flower, score: 84.277	N	N	N	N
vg0223522667	G -> T	LOC_Os02g38920.1	upstream_gene_variant ; 4851.0bp to feature; MODIFIER	silent_mutation	Average:75.739; most accessible tissue: Minghui63 flower, score: 84.277	N	N	N	N
vg0223522667	G -> T	LOC_Os02g38910-LOC_Os02g38920	intergenic_region ; MODIFIER	silent_mutation	Average:75.739; most accessible tissue: Minghui63 flower, score: 84.277	N	N	N	N
vg0223522667	G -> DEL	N	N	silent_mutation	Average:75.739; most accessible tissue: Minghui63 flower, score: 84.277	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0223522667	G	T	0.01	-0.01	-0.02	0.02	0.01	0.02

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0223522667	3.75E-06	3.75E-06	mr1192_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	NA	6.68E-06	mr1278_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	3.84E-06	3.84E-06	mr1312_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	1.38E-06	1.38E-06	mr1329_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	1.66E-06	1.66E-06	mr1337_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	4.27E-06	4.27E-06	mr1374_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	1.34E-06	1.34E-06	mr1524_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	NA	2.76E-06	mr1600_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	5.54E-06	3.14E-06	mr1645_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	2.12E-06	3.62E-08	mr1648_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	7.79E-07	7.79E-07	mr1663_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0223522667	7.42E-07	7.42E-07	mr1697_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251