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Detailed information for vg0222316237:

Variant ID: vg0222316237 (JBrowse)	Variation Type: SNP
Chromosome: chr02	Position: 22316237
Reference Allele: C	Alternative Allele: T
Primary Allele: T	Secondary Allele: C

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

GGTCACACATATCATACACACGTAGCGTTTTAGAATCCGTGCTGCAGCTGGCTACAAATATATAGTCCGCTTATCTTCTCTCTTTTCTTATCTTCCGTAC[C/T]
GCAGCTGGCTATAAATATATAGCCGACATTATGTTAGGGCCTCATCGGATGGATGTATGGGCTGAGGCTTTTCAGCCAAAGCCTATCGAATTGCTTATTG

Reverse complement sequence

CAATAAGCAATTCGATAGGCTTTGGCTGAAAAGCCTCAGCCCATACATCCATCCGATGAGGCCCTAACATAATGTCGGCTATATATTTATAGCCAGCTGC[G/A]
GTACGGAAGATAAGAAAAGAGAGAAGATAAGCGGACTATATATTTGTAGCCAGCTGCAGCACGGATTCTAAAACGCTACGTGTGTATGATATGTGTGACC

Allele Frequencies:

Populations	Population Size	Frequency of T(primary allele)	Frequency of C(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	65.20%	34.40%	0.19%	0.21%	NA
All Indica	2759	90.40%	9.40%	0.04%	0.18%	NA
All Japonica	1512	15.80%	83.60%	0.33%	0.26%	NA
Aus	269	99.60%	0.40%	0.00%	0.00%	NA
Indica I	595	85.00%	14.60%	0.00%	0.34%	NA
Indica II	465	99.60%	0.40%	0.00%	0.00%	NA
Indica III	913	90.40%	9.40%	0.11%	0.11%	NA
Indica Intermediate	786	89.20%	10.60%	0.00%	0.25%	NA
Temperate Japonica	767	20.30%	78.90%	0.52%	0.26%	NA
Tropical Japonica	504	10.70%	88.90%	0.00%	0.40%	NA
Japonica Intermediate	241	12.00%	87.60%	0.41%	0.00%	NA
VI/Aromatic	96	35.40%	64.60%	0.00%	0.00%	NA
Intermediate	90	51.10%	44.40%	3.33%	1.11%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0222316237	C -> T	LOC_Os02g36940.1	upstream_gene_variant ; 3075.0bp to feature; MODIFIER	silent_mutation	Average:90.653; most accessible tissue: Minghui63 young leaf, score: 95.808	N	N	N	N
vg0222316237	C -> T	LOC_Os02g36950.1	downstream_gene_variant ; 3618.0bp to feature; MODIFIER	silent_mutation	Average:90.653; most accessible tissue: Minghui63 young leaf, score: 95.808	N	N	N	N
vg0222316237	C -> T	LOC_Os02g36950.2	downstream_gene_variant ; 3618.0bp to feature; MODIFIER	silent_mutation	Average:90.653; most accessible tissue: Minghui63 young leaf, score: 95.808	N	N	N	N
vg0222316237	C -> T	LOC_Os02g36940-LOC_Os02g36950	intergenic_region ; MODIFIER	silent_mutation	Average:90.653; most accessible tissue: Minghui63 young leaf, score: 95.808	N	N	N	N
vg0222316237	C -> DEL	N	N	silent_mutation	Average:90.653; most accessible tissue: Minghui63 young leaf, score: 95.808	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0222316237	C	T	0.06	0.0	0.01	0.05	0.06	0.06

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0222316237	NA	3.98E-06	Awn_length	Ind_All	Not	Breeding signatures of rice improvement revealed by a genomic variation map from a large germplasm collection, Proc Natl Acad Sci USA, 112(39): E5411-E5419, PMID:26358652
vg0222316237	1.04E-06	NA	mr1067	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0222316237	4.40E-06	NA	mr1087_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0222316237	NA	1.30E-09	mr1947_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251