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Detailed information for vg0106772114:

Variant ID: vg0106772114 (JBrowse)Variation Type: SNP
Chromosome: chr01Position: 6772114
Reference Allele: TAlternative Allele: G
Primary Allele: TSecondary Allele: G

Inferred Ancestral Allele : T (evidence from allele frequency in Oryza rufipogon: T: 0.97, G: 0.02, others allele: 0.00, population size: 122. )

Flanking Sequence (100 bp) in Reference Genome:


AACTGGAATACCAGCCTCGTATAAATATACGTACAGCCGTACACTGACTCACTGCTCACCGGCCGCCGTCTCCGTTTGTCGTACACAAAACTCACTGCTA[T/G]
ATACACCCTCCATCCTAAAATAAGTTCATTTATAGGTCTCTATGGTTCAACGTCTGACTGTCAATCTTATTTAAATAATTAAAAAGGTAAAAGCCATATA

Reverse complement sequence

TATATGGCTTTTACCTTTTTAATTATTTAAATAAGATTGACAGTCAGACGTTGAACCATAGAGACCTATAAATGAACTTATTTTAGGATGGAGGGTGTAT[A/C]
TAGCAGTGAGTTTTGTGTACGACAAACGGAGACGGCGGCCGGTGAGCAGTGAGTCAGTGTACGGCTGTACGTATATTTATACGAGGCTGGTATTCCAGTT

Allele Frequencies:

Populations Population SizeFrequency of T(primary allele) Frequency of G(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 65.80% 33.50% 0.68% 0.00% NA
All Indica  2759 69.10% 30.50% 0.40% 0.00% NA
All Japonica  1512 75.60% 23.10% 1.26% 0.00% NA
Aus  269 0.70% 99.30% 0.00% 0.00% NA
Indica I  595 86.20% 13.10% 0.67% 0.00% NA
Indica II  465 52.70% 47.30% 0.00% 0.00% NA
Indica III  913 76.70% 23.00% 0.33% 0.00% NA
Indica Intermediate  786 57.10% 42.40% 0.51% 0.00% NA
Temperate Japonica  767 80.80% 17.10% 2.09% 0.00% NA
Tropical Japonica  504 68.30% 31.70% 0.00% 0.00% NA
Japonica Intermediate  241 74.30% 24.50% 1.24% 0.00% NA
VI/Aromatic  96 9.40% 90.60% 0.00% 0.00% NA
Intermediate  90 55.60% 42.20% 2.22% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0106772114 T -> G LOC_Os01g12390.1 upstream_gene_variant ; 1950.0bp to feature; MODIFIER silent_mutation Average:74.719; most accessible tissue: Minghui63 root, score: 94.472 N N N N
vg0106772114 T -> G LOC_Os01g12400.2 downstream_gene_variant ; 2086.0bp to feature; MODIFIER silent_mutation Average:74.719; most accessible tissue: Minghui63 root, score: 94.472 N N N N
vg0106772114 T -> G LOC_Os01g12390-LOC_Os01g12400 intergenic_region ; MODIFIER silent_mutation Average:74.719; most accessible tissue: Minghui63 root, score: 94.472 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0106772114 T G -0.1 -0.06 -0.04 -0.03 -0.02 -0.01

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0106772114 NA 7.12E-06 mr1236 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 2.71E-09 3.79E-14 mr1498 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 4.80E-07 NA mr1498 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 NA 8.51E-06 mr1633 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 7.10E-08 NA mr1769 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 NA 8.65E-09 mr1925 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 NA 6.36E-06 mr1925 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 8.51E-07 1.84E-12 mr1951 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 1.23E-06 2.76E-06 mr1236_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 NA 3.94E-09 mr1236_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 5.35E-11 1.09E-12 mr1498_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 2.68E-09 8.05E-11 mr1498_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 NA 6.02E-06 mr1577_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 9.58E-09 NA mr1769_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 3.99E-07 NA mr1769_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 1.80E-09 3.71E-11 mr1925_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 3.06E-07 7.25E-09 mr1925_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 1.53E-08 1.33E-12 mr1951_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 1.60E-07 1.51E-08 mr1951_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0106772114 NA 3.41E-08 mr1959_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251