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Detailed information for vg1124910912:

Variant ID: vg1124910912 (JBrowse)	Variation Type: SNP
Chromosome: chr11	Position: 24910912
Reference Allele: C	Alternative Allele: T
Primary Allele: C	Secondary Allele: T

Inferred Ancestral Allele : C (evidence from allele frequency in Oryza rufipogon: C: 1.00, others allele: 0.00, population size: 291. )

Flanking Sequence (100 bp) in Reference Genome:

CGCGTCAATATGAAAGATCGATGAAGCTAGGGCGCGCTGGCATACACCGAGAGATCGTCATGGCCAGCCGCCGTCGCTAGGTTTGGAACAGGCTCCATCG[C/T]
TGTTTAAAAATCCCACCTGCGCCGTGTTCCCATCTGCTAATGGCTGAACGATTGATACAAGGATAATGATCGGTTGTTGATTGGATGCATCCACATATAC

Reverse complement sequence

GTATATGTGGATGCATCCAATCAACAACCGATCATTATCCTTGTATCAATCGTTCAGCCATTAGCAGATGGGAACACGGCGCAGGTGGGATTTTTAAACA[G/A]
CGATGGAGCCTGTTCCAAACCTAGCGACGGCGGCTGGCCATGACGATCTCTCGGTGTATGCCAGCGCGCCCTAGCTTCATCGATCTTTCATATTGACGCG

Allele Frequencies:

Populations	Population Size	Frequency of C(primary allele)	Frequency of T(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	90.50%	0.10%	0.38%	9.01%	NA
All Indica	2759	86.60%	0.10%	0.62%	12.69%	NA
All Japonica	1512	99.50%	0.00%	0.00%	0.46%	NA
Aus	269	74.70%	0.00%	0.37%	24.91%	NA
Indica I	595	79.80%	0.00%	0.67%	19.50%	NA
Indica II	465	65.80%	0.00%	2.58%	31.61%	NA
Indica III	913	98.80%	0.10%	0.00%	1.10%	NA
Indica Intermediate	786	89.70%	0.40%	0.13%	9.80%	NA
Temperate Japonica	767	99.50%	0.00%	0.00%	0.52%	NA
Tropical Japonica	504	99.60%	0.00%	0.00%	0.40%	NA
Japonica Intermediate	241	99.60%	0.00%	0.00%	0.41%	NA
VI/Aromatic	96	100.00%	0.00%	0.00%	0.00%	NA
Intermediate	90	97.80%	0.00%	0.00%	2.22%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg1124910912	C -> T	LOC_Os11g41530.1	upstream_gene_variant ; 2851.0bp to feature; MODIFIER	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N
vg1124910912	C -> T	LOC_Os11g41540.1	upstream_gene_variant ; 589.0bp to feature; MODIFIER	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N
vg1124910912	C -> T	LOC_Os11g41540.2	upstream_gene_variant ; 589.0bp to feature; MODIFIER	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N
vg1124910912	C -> T	LOC_Os11g41540.3	upstream_gene_variant ; 589.0bp to feature; MODIFIER	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N
vg1124910912	C -> T	LOC_Os11g41540.4	upstream_gene_variant ; 589.0bp to feature; MODIFIER	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N
vg1124910912	C -> T	LOC_Os11g41530-LOC_Os11g41540	intergenic_region ; MODIFIER	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N
vg1124910912	C -> DEL	N	N	silent_mutation	Average:44.423; most accessible tissue: Minghui63 root, score: 92.561	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg1124910912	C	T	0.3	0.01	-0.01	-0.02	-0.01	-0.03

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg1124910912	NA	7.58E-08	mr1133	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	2.98E-06	9.97E-08	mr1238	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	NA	2.94E-06	mr1309	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	NA	1.88E-06	mr1841	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	3.72E-07	2.93E-09	mr1238_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	NA	4.17E-06	mr1380_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	NA	4.39E-06	mr1380_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	1.99E-06	7.17E-08	mr1484_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	NA	3.07E-08	mr1841_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1124910912	NA	2.28E-08	mr1900_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251