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Detailed information for vg1010118291:

Variant ID: vg1010118291 (JBrowse)Variation Type: SNP
Chromosome: chr10Position: 10118291
Reference Allele: AAlternative Allele: G
Primary Allele: ASecondary Allele: G

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:


CGCATCCTGGTACCAGAAAGCTTGTTGCTTCTGACGGCTAATATATTTTTGATGATGTGGCACATCCTCGTACCAAAAAGCTCTGCTTTCCCTATATAAG[A/G]
TAAGATTCGTAGTTTTATTTTATTTATAAATGACAAAAATCTATTCCTACTCACAGATCTTGAGTGATTTTTTTTAATTATTTCCTAAATAAAATTCCCG

Reverse complement sequence

CGGGAATTTTATTTAGGAAATAATTAAAAAAAATCACTCAAGATCTGTGAGTAGGAATAGATTTTTGTCATTTATAAATAAAATAAAACTACGAATCTTA[T/C]
CTTATATAGGGAAAGCAGAGCTTTTTGGTACGAGGATGTGCCACATCATCAAAAATATATTAGCCGTCAGAAGCAACAAGCTTTCTGGTACCAGGATGCG

Allele Frequencies:

Populations Population SizeFrequency of A(primary allele) Frequency of G(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 97.00% 3.00% 0.00% 0.00% NA
All Indica  2759 100.00% 0.00% 0.00% 0.00% NA
All Japonica  1512 90.50% 9.50% 0.00% 0.00% NA
Aus  269 100.00% 0.00% 0.00% 0.00% NA
Indica I  595 99.80% 0.20% 0.00% 0.00% NA
Indica II  465 100.00% 0.00% 0.00% 0.00% NA
Indica III  913 100.00% 0.00% 0.00% 0.00% NA
Indica Intermediate  786 100.00% 0.00% 0.00% 0.00% NA
Temperate Japonica  767 83.40% 16.60% 0.00% 0.00% NA
Tropical Japonica  504 97.40% 2.60% 0.00% 0.00% NA
Japonica Intermediate  241 98.80% 1.20% 0.00% 0.00% NA
VI/Aromatic  96 100.00% 0.00% 0.00% 0.00% NA
Intermediate  90 100.00% 0.00% 0.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg1010118291 A -> G LOC_Os10g20160.1 downstream_gene_variant ; 1672.0bp to feature; MODIFIER silent_mutation Average:88.751; most accessible tissue: Zhenshan97 panicle, score: 94.112 N N N N
vg1010118291 A -> G LOC_Os10g20139-LOC_Os10g20160 intergenic_region ; MODIFIER silent_mutation Average:88.751; most accessible tissue: Zhenshan97 panicle, score: 94.112 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg1010118291 A G -0.13 -0.08 -0.07 -0.05 -0.07 -0.08

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg1010118291 NA 2.14E-07 mr1006 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 NA 3.11E-06 mr1007 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 NA 6.26E-07 mr1052 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 5.98E-06 3.55E-07 mr1095 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 2.51E-06 2.51E-06 mr1488 Jap_All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 NA 5.34E-06 mr1788 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 2.31E-06 2.31E-06 mr1950 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1010118291 NA 1.33E-07 mr1585_2 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251