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Detailed information for vg0909366654:

Variant ID: vg0909366654 (JBrowse)Variation Type: SNP
Chromosome: chr09Position: 9366654
Reference Allele: TAlternative Allele: C
Primary Allele: TSecondary Allele: C

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:


ATCAAGTCTTAATCACCACCCACTAAAACCTTATTAAACCATCATCAATTCATTATCATCATCATCTAAACCTCCGACGAGCCGGACTTGGCGGCGGCGG[T/C]
TGGCATGGCGGCCATCTGGTGGTGGTGGTGGCCCTGATACTTGGGGTCCTTCCTGACGATGCGCTTCCAATACCAGTGCTTGTCGAAGAGCATCCAGATC

Reverse complement sequence

GATCTGGATGCTCTTCGACAAGCACTGGTATTGGAAGCGCATCGTCAGGAAGGACCCCAAGTATCAGGGCCACCACCACCACCAGATGGCCGCCATGCCA[A/G]
CCGCCGCCGCCAAGTCCGGCTCGTCGGAGGTTTAGATGATGATGATAATGAATTGATGATGGTTTAATAAGGTTTTAGTGGGTGGTGATTAAGACTTGAT

Allele Frequencies:

Populations Population SizeFrequency of T(primary allele) Frequency of C(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 92.20% 7.80% 0.00% 0.00% NA
All Indica  2759 98.80% 1.20% 0.00% 0.00% NA
All Japonica  1512 86.60% 13.40% 0.00% 0.00% NA
Aus  269 52.00% 48.00% 0.00% 0.00% NA
Indica I  595 100.00% 0.00% 0.00% 0.00% NA
Indica II  465 100.00% 0.00% 0.00% 0.00% NA
Indica III  913 99.70% 0.30% 0.00% 0.00% NA
Indica Intermediate  786 96.10% 3.90% 0.00% 0.00% NA
Temperate Japonica  767 91.90% 8.10% 0.00% 0.00% NA
Tropical Japonica  504 87.70% 12.30% 0.00% 0.00% NA
Japonica Intermediate  241 67.60% 32.40% 0.00% 0.00% NA
VI/Aromatic  96 100.00% 0.00% 0.00% 0.00% NA
Intermediate  90 96.70% 3.30% 0.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0909366654 T -> C LOC_Os09g15330.1 missense_variant ; p.Asn520Ser; MODERATE nonsynonymous_codon Average:86.862; most accessible tissue: Zhenshan97 panicle, score: 94.112 unknown unknown DELETERIOUS 0.00
vg0909366654 T -> C LOC_Os09g15330.2 missense_variant ; p.Asn520Ser; MODERATE nonsynonymous_codon Average:86.862; most accessible tissue: Zhenshan97 panicle, score: 94.112 unknown unknown DELETERIOUS 0.00

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0909366654 T C -0.01 -0.01 -0.01 0.0 -0.01 -0.01

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0909366654 NA 1.57E-06 mr1286 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0909366654 NA 3.57E-14 mr1496 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0909366654 8.73E-07 9.37E-14 mr1720 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0909366654 NA 4.21E-07 mr1777 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0909366654 9.90E-06 2.80E-09 mr1705_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0909366654 NA 1.23E-07 mr1740_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251