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Detailed information for vg0900731282:

Variant ID: vg0900731282 (JBrowse)Variation Type: SNP
Chromosome: chr09Position: 731282
Reference Allele: GAlternative Allele: A
Primary Allele: GSecondary Allele: A

Inferred Ancestral Allele : G (evidence from allele frequency in Oryza rufipogon: G: 1.00, others allele: 0.00, population size: 127. )

Flanking Sequence (100 bp) in Reference Genome:


GTGAAAGCCTAGTCTTGGCTCCTTTGAGTCCCAACGGACGGCGGCGGCGGTTTTTCTGTCGCTTCTCTTCTTGAAGATGTCGTTCTGGCATCCCCTAGGG[G/A]
GCGATCTCGTCTGTGTCCCTTTGTTGGTCTAGTGGCGATCGGTCACGCTTAGCGGCGGTCGATCCGGTGCTAGCCTTCTCCTGGGTTTGTGTGTTGGCGA

Reverse complement sequence

TCGCCAACACACAAACCCAGGAGAAGGCTAGCACCGGATCGACCGCCGCTAAGCGTGACCGATCGCCACTAGACCAACAAAGGGACACAGACGAGATCGC[C/T]
CCCTAGGGGATGCCAGAACGACATCTTCAAGAAGAGAAGCGACAGAAAAACCGCCGCCGCCGTCCGTTGGGACTCAAAGGAGCCAAGACTAGGCTTTCAC

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of A(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 68.80% 4.80% 26.36% 0.08% NA
All Indica  2759 47.60% 8.10% 44.18% 0.14% NA
All Japonica  1512 99.40% 0.00% 0.60% 0.00% NA
Aus  269 100.00% 0.00% 0.00% 0.00% NA
Indica I  595 49.40% 3.40% 46.89% 0.34% NA
Indica II  465 35.50% 13.50% 50.97% 0.00% NA
Indica III  913 49.30% 10.00% 40.74% 0.00% NA
Indica Intermediate  786 51.30% 6.40% 42.11% 0.25% NA
Temperate Japonica  767 99.50% 0.00% 0.52% 0.00% NA
Tropical Japonica  504 99.40% 0.00% 0.60% 0.00% NA
Japonica Intermediate  241 99.20% 0.00% 0.83% 0.00% NA
VI/Aromatic  96 100.00% 0.00% 0.00% 0.00% NA
Intermediate  90 77.80% 2.20% 20.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0900731282 G -> DEL N N silent_mutation Average:40.633; most accessible tissue: Zhenshan97 flag leaf, score: 80.799 N N N N
vg0900731282 G -> A LOC_Os09g02030.1 downstream_gene_variant ; 701.0bp to feature; MODIFIER silent_mutation Average:40.633; most accessible tissue: Zhenshan97 flag leaf, score: 80.799 N N N N
vg0900731282 G -> A LOC_Os09g02020-LOC_Os09g02030 intergenic_region ; MODIFIER silent_mutation Average:40.633; most accessible tissue: Zhenshan97 flag leaf, score: 80.799 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0900731282 G A -0.01 -0.01 -0.01 -0.01 -0.01 -0.01

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0900731282 NA 8.77E-09 mr1157 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0900731282 6.40E-06 7.26E-08 mr1157 Ind_All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0900731282 NA 5.36E-07 mr1328 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0900731282 NA 4.56E-06 mr1328 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0900731282 NA 5.06E-06 mr1446 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251