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Detailed information for vg0727589348:

Variant ID: vg0727589348 (JBrowse)	Variation Type: SNP
Chromosome: chr07	Position: 27589348
Reference Allele: G	Alternative Allele: A
Primary Allele: G	Secondary Allele: A

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

GAATCTGGACAGATGTGTCACATGCACCCATTATCTATTATATTATGGGACGGAGGGAGTAAGGCCTGGTTTAGTTCATAAATTTTTTTTTCTCAAAAAC[G/A]
TCACATCAAATCTTTAAACACATGTATGGAGCATTAAATACAGATAAAAACAAAAACTATTTGCACAATTTGCATGGAATCCGCGAGACGAATCTTTTAA

Reverse complement sequence

TTAAAAGATTCGTCTCGCGGATTCCATGCAAATTGTGCAAATAGTTTTTGTTTTTATCTGTATTTAATGCTCCATACATGTGTTTAAAGATTTGATGTGA[C/T]
GTTTTTGAGAAAAAAAAATTTATGAACTAAACCAGGCCTTACTCCCTCCGTCCCATAATATAATAGATAATGGGTGCATGTGACACATCTGTCCAGATTC

Allele Frequencies:

Populations	Population Size	Frequency of G(primary allele)	Frequency of A(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	78.70%	21.20%	0.06%	0.00%	NA
All Indica	2759	93.00%	7.00%	0.00%	0.00%	NA
All Japonica	1512	47.50%	52.40%	0.13%	0.00%	NA
Aus	269	98.50%	1.50%	0.00%	0.00%	NA
Indica I	595	96.60%	3.40%	0.00%	0.00%	NA
Indica II	465	98.30%	1.70%	0.00%	0.00%	NA
Indica III	913	98.10%	1.90%	0.00%	0.00%	NA
Indica Intermediate	786	81.30%	18.70%	0.00%	0.00%	NA
Temperate Japonica	767	67.50%	32.50%	0.00%	0.00%	NA
Tropical Japonica	504	23.80%	76.00%	0.20%	0.00%	NA
Japonica Intermediate	241	33.20%	66.40%	0.41%	0.00%	NA
VI/Aromatic	96	100.00%	0.00%	0.00%	0.00%	NA
Intermediate	90	83.30%	15.60%	1.11%	0.00%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0727589348	G -> A	LOC_Os07g46230.1	downstream_gene_variant ; 1986.0bp to feature; MODIFIER	silent_mutation	Average:76.328; most accessible tissue: Minghui63 flag leaf, score: 95.423	N	N	N	N
vg0727589348	G -> A	LOC_Os07g46240.1	downstream_gene_variant ; 1093.0bp to feature; MODIFIER	silent_mutation	Average:76.328; most accessible tissue: Minghui63 flag leaf, score: 95.423	N	N	N	N
vg0727589348	G -> A	LOC_Os07g46230-LOC_Os07g46240	intergenic_region ; MODIFIER	silent_mutation	Average:76.328; most accessible tissue: Minghui63 flag leaf, score: 95.423	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0727589348	G	A	-0.05	-0.05	-0.01	-0.02	-0.02	-0.01

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0727589348	NA	9.37E-11	mr1002	Jap_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	2.26E-10	mr1578	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	1.22E-06	mr1705	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	1.60E-07	mr1915	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	3.01E-10	mr1002_2	Jap_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	2.15E-06	mr1011_2	Jap_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	7.15E-06	mr1186_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	3.21E-09	mr1369_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	1.93E-06	1.93E-06	mr1369_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	4.38E-09	mr1453_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	3.56E-06	3.56E-06	mr1453_2	Ind_All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	2.25E-07	mr1616_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	1.75E-07	mr1652_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0727589348	NA	8.42E-06	mr1706_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251