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Detailed information for vg0621488776:

Variant ID: vg0621488776 (JBrowse)	Variation Type: SNP
Chromosome: chr06	Position: 21488776
Reference Allele: A	Alternative Allele: G
Primary Allele: A	Secondary Allele: G

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

CAGCCAAATCTCATCAAGCCATCTCCCTCCACCCAAAAGCTGGATTGTGTTTGGTCGTCTCCCTCTCTCCACCACTCCCACCCAACTAGTACCGTTGGAG[A/G]
AGGACCGAATAAGGTTATATCTACGGAGCTCAAAATTCAGAGAAGCAGATAAATAGACACTTAATAGGAATATAAAAATATTTCCCAGTTTTTGATTTTT

Reverse complement sequence

AAAAATCAAAAACTGGGAAATATTTTTATATTCCTATTAAGTGTCTATTTATCTGCTTCTCTGAATTTTGAGCTCCGTAGATATAACCTTATTCGGTCCT[T/C]
CTCCAACGGTACTAGTTGGGTGGGAGTGGTGGAGAGAGGGAGACGACCAAACACAATCCAGCTTTTGGGTGGAGGGAGATGGCTTGATGAGATTTGGCTG

Allele Frequencies:

Populations	Population Size	Frequency of A(primary allele)	Frequency of G(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	66.40%	27.80%	2.24%	3.60%	NA
All Indica	2759	78.50%	11.70%	3.70%	6.09%	NA
All Japonica	1512	57.70%	42.10%	0.20%	0.00%	NA
Aus	269	0.00%	100.00%	0.00%	0.00%	NA
Indica I	595	89.20%	0.80%	9.75%	0.17%	NA
Indica II	465	77.60%	15.70%	3.44%	3.23%	NA
Indica III	913	68.50%	18.30%	0.11%	13.14%	NA
Indica Intermediate	786	82.60%	9.90%	3.44%	4.07%	NA
Temperate Japonica	767	47.20%	52.50%	0.26%	0.00%	NA
Tropical Japonica	504	77.80%	22.00%	0.20%	0.00%	NA
Japonica Intermediate	241	49.40%	50.60%	0.00%	0.00%	NA
VI/Aromatic	96	27.10%	72.90%	0.00%	0.00%	NA
Intermediate	90	80.00%	16.70%	1.11%	2.22%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0621488776	A -> G	LOC_Os06g36570.1	upstream_gene_variant ; 4259.0bp to feature; MODIFIER	silent_mutation	Average:84.825; most accessible tissue: Zhenshan97 flower, score: 94.812	N	N	N	N
vg0621488776	A -> G	LOC_Os06g36590.1	upstream_gene_variant ; 4358.0bp to feature; MODIFIER	silent_mutation	Average:84.825; most accessible tissue: Zhenshan97 flower, score: 94.812	N	N	N	N
vg0621488776	A -> G	LOC_Os06g36580.1	downstream_gene_variant ; 990.0bp to feature; MODIFIER	silent_mutation	Average:84.825; most accessible tissue: Zhenshan97 flower, score: 94.812	N	N	N	N
vg0621488776	A -> G	LOC_Os06g36570-LOC_Os06g36580	intergenic_region ; MODIFIER	silent_mutation	Average:84.825; most accessible tissue: Zhenshan97 flower, score: 94.812	N	N	N	N
vg0621488776	A -> DEL	N	N	silent_mutation	Average:84.825; most accessible tissue: Zhenshan97 flower, score: 94.812	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0621488776	A	G	-0.09	-0.13	-0.1	0.0	-0.04	0.0

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0621488776	NA	8.37E-10	mr1465	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0621488776	4.30E-08	5.60E-09	mr1695	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0621488776	NA	1.82E-07	mr1126_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0621488776	NA	9.08E-09	mr1364_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0621488776	NA	3.78E-14	mr1583_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0621488776	2.78E-11	2.41E-12	mr1695_2	Ind_All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0621488776	NA	1.02E-15	mr1807_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251