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Detailed information for vg0432680673:

Variant ID: vg0432680673 (JBrowse)Variation Type: SNP
Chromosome: chr04Position: 32680673
Reference Allele: GAlternative Allele: T
Primary Allele: GSecondary Allele: T

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:


TTTTTTATATTTACACTAATTTTTTAAATAAAACGAATGGTCAAACGTTGCAAATAAAAAGTCAAAAACGTCATCTATTATAATACGGAGTGAGTAGGTA[G/T]
TAGTGTAGGAGTAGCTACTAATACACGTAGTATACTGTCTCTGTTCCTTTCTAAATGCTTGTTCATGTTGCTTTCCAAATGCTTACTGATAGCATTTGAA

Reverse complement sequence

TTCAAATGCTATCAGTAAGCATTTGGAAAGCAACATGAACAAGCATTTAGAAAGGAACAGAGACAGTATACTACGTGTATTAGTAGCTACTCCTACACTA[C/A]
TACCTACTCACTCCGTATTATAATAGATGACGTTTTTGACTTTTTATTTGCAACGTTTGACCATTCGTTTTATTTAAAAAATTAGTGTAAATATAAAAAA

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of T(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 92.60% 7.40% 0.04% 0.00% NA
All Indica  2759 99.80% 0.20% 0.00% 0.00% NA
All Japonica  1512 77.80% 22.00% 0.13% 0.00% NA
Aus  269 98.50% 1.50% 0.00% 0.00% NA
Indica I  595 99.80% 0.20% 0.00% 0.00% NA
Indica II  465 100.00% 0.00% 0.00% 0.00% NA
Indica III  913 99.90% 0.10% 0.00% 0.00% NA
Indica Intermediate  786 99.50% 0.50% 0.00% 0.00% NA
Temperate Japonica  767 99.00% 1.00% 0.00% 0.00% NA
Tropical Japonica  504 37.30% 62.30% 0.40% 0.00% NA
Japonica Intermediate  241 95.40% 4.60% 0.00% 0.00% NA
VI/Aromatic  96 100.00% 0.00% 0.00% 0.00% NA
Intermediate  90 92.20% 7.80% 0.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0432680673 G -> T LOC_Os04g54930.1 upstream_gene_variant ; 2353.0bp to feature; MODIFIER silent_mutation Average:64.93; most accessible tissue: Minghui63 panicle, score: 93.735 N N N N
vg0432680673 G -> T LOC_Os04g54940.1 upstream_gene_variant ; 3872.0bp to feature; MODIFIER silent_mutation Average:64.93; most accessible tissue: Minghui63 panicle, score: 93.735 N N N N
vg0432680673 G -> T LOC_Os04g54930-LOC_Os04g54940 intergenic_region ; MODIFIER silent_mutation Average:64.93; most accessible tissue: Minghui63 panicle, score: 93.735 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0432680673 G T -0.09 -0.13 -0.11 -0.08 -0.17 -0.17

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0432680673 NA 3.95E-07 mr1229 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 2.57E-07 mr1229 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 1.47E-06 NA mr1241 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 1.52E-11 mr1241 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 4.92E-06 mr1319 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 1.03E-07 mr1403 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 6.31E-06 mr1596 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 3.80E-07 mr1671 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 3.38E-08 mr1880 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 7.69E-10 mr1319_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0432680673 NA 5.09E-06 mr1319_2 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251