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Detailed information for vg0324825826:

Variant ID: vg0324825826 (JBrowse)Variation Type: SNP
Chromosome: chr03Position: 24825826
Reference Allele: TAlternative Allele: G
Primary Allele: TSecondary Allele: G

Inferred Ancestral Allele : T (evidence from allele frequency in Oryza rufipogon: T: 0.53, G: 0.48, others allele: 0.00, population size: 101. )

Flanking Sequence (100 bp) in Reference Genome:


GCGCGATGGTTTCGCTTATTTGCACCGGCCGGCCAATCGCGGCGCCGGCGAGCTCATTTTGATCTCAGCCGTCGAGGCCGAAGTGCTTCCTCATGCCGCA[T/G]
GCGAACTGGTACACGAACTCGGGATCCGGCAGCGACGCCGCCACGCACGCGTTCTCCCGGACGCACCGCGCCGCCCACGCCGCCAGCTCCGGGCACTCCG

Reverse complement sequence

CGGAGTGCCCGGAGCTGGCGGCGTGGGCGGCGCGGTGCGTCCGGGAGAACGCGTGCGTGGCGGCGTCGCTGCCGGATCCCGAGTTCGTGTACCAGTTCGC[A/C]
TGCGGCATGAGGAAGCACTTCGGCCTCGACGGCTGAGATCAAAATGAGCTCGCCGGCGCCGCGATTGGCCGGCCGGTGCAAATAAGCGAAACCATCGCGC

Allele Frequencies:

Populations Population SizeFrequency of T(primary allele) Frequency of G(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 66.90% 33.10% 0.04% 0.00% NA
All Indica  2759 44.70% 55.30% 0.07% 0.00% NA
All Japonica  1512 99.30% 0.70% 0.00% 0.00% NA
Aus  269 99.60% 0.40% 0.00% 0.00% NA
Indica I  595 82.50% 17.50% 0.00% 0.00% NA
Indica II  465 10.50% 89.50% 0.00% 0.00% NA
Indica III  913 33.20% 66.70% 0.11% 0.00% NA
Indica Intermediate  786 49.50% 50.40% 0.13% 0.00% NA
Temperate Japonica  767 99.30% 0.70% 0.00% 0.00% NA
Tropical Japonica  504 99.40% 0.60% 0.00% 0.00% NA
Japonica Intermediate  241 99.20% 0.80% 0.00% 0.00% NA
VI/Aromatic  96 99.00% 1.00% 0.00% 0.00% NA
Intermediate  90 72.20% 27.80% 0.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0324825826 T -> G LOC_Os03g44170.1 synonymous_variant ; p.Ala221Ala; LOW synonymous_codon Average:84.942; most accessible tissue: Minghui63 flower, score: 93.156 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0324825826 T G 0.04 0.03 0.04 0.02 0.02 0.0

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0324825826 NA 4.24E-06 mr1629 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0324825826 NA 1.41E-07 mr1671 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0324825826 NA 4.26E-09 mr1928 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0324825826 NA 2.00E-06 mr1928 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0324825826 NA 5.15E-07 mr1951 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251