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Detailed information for vg1107617628:

Variant ID: vg1107617628 (JBrowse)Variation Type: SNP
Chromosome: chr11Position: 7617628
Reference Allele: GAlternative Allele: A
Primary Allele: GSecondary Allele: A

Inferred Ancestral Allele : G (evidence from allele frequency in Oryza rufipogon: G: 0.99, A: 0.01, others allele: 0.00, population size: 111. )

Flanking Sequence (100 bp) in Reference Genome:


ATATTTGTCTTCCAAATATGGTGACTACATGTATAGATTAGTCTTAAAAAGTACTTTAATAAGATCATATATTTGCTAACAATTTTATATATATTATAAT[G/A]
AAAAATAATGGTCAAAGTTGTTTTTTGGAGACCGTACCCTTGTCCAAAACAACAAGTATTATCAACCCGGAGGGAGTAGAAATGGCTGTGCACTAATTAA

Reverse complement sequence

TTAATTAGTGCACAGCCATTTCTACTCCCTCCGGGTTGATAATACTTGTTGTTTTGGACAAGGGTACGGTCTCCAAAAAACAACTTTGACCATTATTTTT[C/T]
ATTATAATATATATAAAATTGTTAGCAAATATATGATCTTATTAAAGTACTTTTTAAGACTAATCTATACATGTAGTCACCATATTTGGAAGACAAATAT

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of A(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 57.00% 41.90% 1.10% 0.02% NA
All Indica  2759 32.60% 65.70% 1.67% 0.04% NA
All Japonica  1512 93.00% 6.90% 0.07% 0.00% NA
Aus  269 88.50% 10.80% 0.74% 0.00% NA
Indica I  595 10.40% 84.90% 4.71% 0.00% NA
Indica II  465 60.40% 39.40% 0.22% 0.00% NA
Indica III  913 27.80% 71.10% 0.99% 0.11% NA
Indica Intermediate  786 38.50% 60.40% 1.02% 0.00% NA
Temperate Japonica  767 96.90% 3.10% 0.00% 0.00% NA
Tropical Japonica  504 91.90% 7.90% 0.20% 0.00% NA
Japonica Intermediate  241 83.00% 17.00% 0.00% 0.00% NA
VI/Aromatic  96 97.90% 2.10% 0.00% 0.00% NA
Intermediate  90 63.30% 33.30% 3.33% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg1107617628 G -> A LOC_Os11g13830.1 upstream_gene_variant ; 2371.0bp to feature; MODIFIER silent_mutation Average:66.671; most accessible tissue: Minghui63 root, score: 88.705 N N N N
vg1107617628 G -> A LOC_Os11g13820.1 intron_variant ; MODIFIER silent_mutation Average:66.671; most accessible tissue: Minghui63 root, score: 88.705 N N N N
vg1107617628 G -> DEL N N silent_mutation Average:66.671; most accessible tissue: Minghui63 root, score: 88.705 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg1107617628 G A 0.02 0.04 0.03 0.01 0.01 0.02

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg1107617628 NA 3.10E-06 mr1224 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1107617628 7.76E-06 1.38E-06 mr1894_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1107617628 NA 4.89E-07 mr1925_2 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1107617628 NA 2.62E-06 mr1959_2 Ind_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251