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Detailed information for vg1022972787:

Variant ID: vg1022972787 (JBrowse)Variation Type: SNP
Chromosome: chr10Position: 22972787
Reference Allele: GAlternative Allele: A
Primary Allele: GSecondary Allele: A

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:


AGAGACGATCGATCGAGATGCATGCATGCACCTGCCTGCGGTATGCTATACTAGATACCAAGCCAATCGTCGTATGCAGATGTCACTAGCTACTCCATCC[G/A]
TTTCACAATGTAAGTCACTTTAGCATTTTTCACATTTATATTGATGTTAATATATATATATATATATATATATATATATATATATATATATATATATATA

Reverse complement sequence

TATATATATATATATATATATATATATATATATATATATATATATATATATTAACATCAATATAAATGTGAAAAATGCTAAAGTGACTTACATTGTGAAA[C/T]
GGATGGAGTAGCTAGTGACATCTGCATACGACGATTGGCTTGGTATCTAGTATAGCATACCGCAGGCAGGTGCATGCATGCATCTCGATCGATCGTCTCT

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of A(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 91.00% 7.20% 0.04% 1.69% NA
All Indica  2759 84.70% 12.30% 0.07% 2.90% NA
All Japonica  1512 99.90% 0.10% 0.00% 0.00% NA
Aus  269 100.00% 0.00% 0.00% 0.00% NA
Indica I  595 71.90% 27.10% 0.34% 0.67% NA
Indica II  465 87.10% 5.20% 0.00% 7.74% NA
Indica III  913 86.10% 11.80% 0.00% 2.08% NA
Indica Intermediate  786 91.50% 5.90% 0.00% 2.67% NA
Temperate Japonica  767 99.90% 0.10% 0.00% 0.00% NA
Tropical Japonica  504 99.80% 0.20% 0.00% 0.00% NA
Japonica Intermediate  241 100.00% 0.00% 0.00% 0.00% NA
VI/Aromatic  96 100.00% 0.00% 0.00% 0.00% NA
Intermediate  90 98.90% 1.10% 0.00% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg1022972787 G -> A LOC_Os10g42610-LOC_Os10g42620 intergenic_region ; MODIFIER silent_mutation Average:4.21; most accessible tissue: Minghui63 panicle, score: 7.125 N N N N
vg1022972787 G -> DEL N N silent_mutation Average:4.21; most accessible tissue: Minghui63 panicle, score: 7.125 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg1022972787 G A 0.01 0.01 0.03 -0.02 -0.01 -0.01

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg1022972787 4.88E-06 5.57E-09 mr1706 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg1022972787 NA 4.08E-08 mr1706 Ind_All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251