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Detailed information for vg0826764899:

Variant ID: vg0826764899 (JBrowse)Variation Type: SNP
Chromosome: chr08Position: 26764899
Reference Allele: AAlternative Allele: G
Primary Allele: GSecondary Allele: A

Inferred Ancestral Allele : A (evidence from allele frequency in Oryza rufipogon: A: 0.77, G: 0.22, others allele: 0.00, population size: 250. )

Flanking Sequence (100 bp) in Reference Genome:


CTGACCTATGCTTGTTGCTTTGATGTCACTAGTAGCTAACTAAGTAGTATATTCTTTGCTGCTAGTGTAGCTTTTTGAACTTATATATTATTTACCAGGA[A/G]
GTAATCAAGATGTATTCATTAGCTGGTCAGTCACTAGTTAATTACTTTGTGCATGCTTTTGTATTGGTATTGTGGAAGAAAAGATTAGCTAAGAGAAGGG

Reverse complement sequence

CCCTTCTCTTAGCTAATCTTTTCTTCCACAATACCAATACAAAAGCATGCACAAAGTAATTAACTAGTGACTGACCAGCTAATGAATACATCTTGATTAC[T/C]
TCCTGGTAAATAATATATAAGTTCAAAAAGCTACACTAGCAGCAAAGAATATACTACTTAGTTAGCTACTAGTGACATCAAAGCAACAAGCATAGGTCAG

Allele Frequencies:

Populations Population SizeFrequency of G(primary allele) Frequency of A(secondary allele) Frequency of N Frequency of DEL Frequency of others Allele
All  4726 68.40% 31.50% 0.06% 0.00% NA
All Indica  2759 98.50% 1.50% 0.00% 0.00% NA
All Japonica  1512 23.40% 76.50% 0.07% 0.00% NA
Aus  269 38.70% 61.00% 0.37% 0.00% NA
Indica I  595 99.30% 0.70% 0.00% 0.00% NA
Indica II  465 97.60% 2.40% 0.00% 0.00% NA
Indica III  913 99.60% 0.40% 0.00% 0.00% NA
Indica Intermediate  786 97.20% 2.80% 0.00% 0.00% NA
Temperate Japonica  767 6.30% 93.60% 0.13% 0.00% NA
Tropical Japonica  504 41.90% 58.10% 0.00% 0.00% NA
Japonica Intermediate  241 39.40% 60.60% 0.00% 0.00% NA
VI/Aromatic  96 3.10% 96.90% 0.00% 0.00% NA
Intermediate  90 58.90% 40.00% 1.11% 0.00% NA

Allele Effect:

Var ID Var Locus snpEff Annotation CooVar Annotation Chromatin Accessibility Score PolyPhen-2 Effect PolyPhen-2 Score SIFT Effect SIFT Score
vg0826764899 A -> G LOC_Os08g42400.1 upstream_gene_variant ; 1917.0bp to feature; MODIFIER silent_mutation Average:77.97; most accessible tissue: Minghui63 root, score: 98.032 N N N N
vg0826764899 A -> G LOC_Os08g42400.2 upstream_gene_variant ; 1917.0bp to feature; MODIFIER silent_mutation Average:77.97; most accessible tissue: Minghui63 root, score: 98.032 N N N N
vg0826764899 A -> G LOC_Os08g42400.3 upstream_gene_variant ; 1917.0bp to feature; MODIFIER silent_mutation Average:77.97; most accessible tissue: Minghui63 root, score: 98.032 N N N N
vg0826764899 A -> G LOC_Os08g42390-LOC_Os08g42400 intergenic_region ; MODIFIER silent_mutation Average:77.97; most accessible tissue: Minghui63 root, score: 98.032 N N N N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID Ref Alt Root (RT) Young Leaf (YL) Flag Leaf (FL) Young Panicle (YP) Lemma & Palea (LP) Stamen & Pistil (SP)
vg0826764899 A G 0.02 -0.01 0.0 -0.02 -0.03 -0.03

Putative Genotype-Phenotype Associations:

Var ID LMM P-value LR P-value Trait Subpopulation Is leadSNP Publication
vg0826764899 NA 3.27E-12 mr1034 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 5.97E-07 mr1040 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 1.11E-15 mr1362 All YES Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 1.11E-07 mr1836 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 5.63E-25 mr1862 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 9.61E-22 mr1401_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 2.07E-07 mr1527_2 All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0826764899 NA 8.15E-07 mr1558_2 Jap_All Not Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251