| Variant ID: vg0504837001 (JBrowse) | Variation Type: INDEL |
| Chromosome: chr05 | Position: 4837001 |
| Reference Allele: CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA | Alternative Allele: AGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA,C |
| Primary Allele: CGAATGCAGGAAAATCACAA TTTCCTTTATAAAGAGTTAA CAAAATTGTCTAGTGAAACA AATGTTAACAAA | Secondary Allele: AGAATGCAGGAAAATCACAA TTTCCTTTATAAAGAGTTAA CAAAATTGTCTAGTGAAACA AATGTTAACAAA |
Inferred Ancestral Allele: Not determined.
AAACAATTTTCAAATGGTCAAATTGTCGAAAATTGTGCCGACATCACGTCCTTAGACTGTCCTGATTTGATCCTAAATGCCTCCAGTAGTCCAGTTTAGC[CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA/AGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA,C]
GGCCGTCTCTCATGTTGGTTTGATTTCCTCCAAATATTCAAGTATAATGTTTTAGATTTTTAATTAAGTTACCTCCTCTGCCTATGTGCTTGTACTCCCA
TGGGAGTACAAGCACATAGGCAGAGGAGGTAACTTAATTAAAAATCTAAAACATTATACTTGAATATTTGGAGGAAATCAAACCAACATGAGAGACGGCC[TTTGTTAACATTTGTTTCACTAGACAATTTTGTTAACTCTTTATAAAGGAAATTGTGATTTTCCTGCATTCG/TTTGTTAACATTTGTTTCACTAGACAATTTTGTTAACTCTTTATAAAGGAAATTGTGATTTTCCTGCATTCT,G]
GCTAAACTGGACTACTGGAGGCATTTAGGATCAAATCAGGACAGTCTAAGGACGTGATGTCGGCACAATTTTCGACAATTTGACCATTTGAAAATTGTTT
| Populations | Population Size | Frequency of CGAATGCAGGAAAATCACAA TTTCCTTTATAAAGAGTTAA CAAAATTGTCTAGTGAAACA AATGTTAACAAA(primary allele) | Frequency of AGAATGCAGGAAAATCACAA TTTCCTTTATAAAGAGTTAA CAAAATTGTCTAGTGAAACA AATGTTAACAAA(secondary allele) | Frequency of N | Frequency of DEL | Frequency of others Allele |
|---|---|---|---|---|---|---|
| All | 4726 | 68.90% | 30.80% | 0.30% | 0.00% | NA |
| All Indica | 2759 | 61.20% | 38.40% | 0.40% | 0.00% | NA |
| All Japonica | 1512 | 92.70% | 7.20% | 0.07% | 0.00% | NA |
| Aus | 269 | 2.20% | 97.40% | 0.37% | 0.00% | NA |
| Indica I | 595 | 90.10% | 9.90% | 0.00% | 0.00% | NA |
| Indica II | 465 | 29.50% | 69.90% | 0.65% | 0.00% | NA |
| Indica III | 913 | 59.70% | 39.90% | 0.44% | 0.00% | NA |
| Indica Intermediate | 786 | 59.90% | 39.60% | 0.51% | 0.00% | NA |
| Temperate Japonica | 767 | 97.00% | 3.00% | 0.00% | 0.00% | NA |
| Tropical Japonica | 504 | 88.10% | 11.70% | 0.20% | 0.00% | NA |
| Japonica Intermediate | 241 | 88.80% | 11.20% | 0.00% | 0.00% | NA |
| VI/Aromatic | 96 | 90.60% | 9.40% | 0.00% | 0.00% | NA |
| Intermediate | 90 | 78.90% | 20.00% | 1.11% | 0.00% | NA |
| Var ID | Var | Locus | snpEff Annotation | CooVar Annotation | Chromatin Accessibility Score | PolyPhen-2 Effect | PolyPhen-2 Score | SIFT Effect | SIFT Score |
|---|---|---|---|---|---|---|---|---|---|
| vg0504837001 | CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA -> AGAATGCAGGAAAATCACAATTTCCTTTAT AAAGAGTTAACAAAATTGTCTAGTGAAACA AATGTTAACAAA | LOC_Os05g08790.1 | upstream_gene_variant ; 1352.0bp to feature; MODIFIER | silent_mutation | Average:75.981; most accessible tissue: Callus, score: 87.204 | N | N | N | N |
| vg0504837001 | CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA -> AGAATGCAGGAAAATCACAATTTCCTTTAT AAAGAGTTAACAAAATTGTCTAGTGAAACA AATGTTAACAAA | LOC_Os05g08800.1 | downstream_gene_variant ; 555.0bp to feature; MODIFIER | silent_mutation | Average:75.981; most accessible tissue: Callus, score: 87.204 | N | N | N | N |
| vg0504837001 | CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA -> AGAATGCAGGAAAATCACAATTTCCTTTAT AAAGAGTTAACAAAATTGTCTAGTGAAACA AATGTTAACAAA | LOC_Os05g08790-LOC_Os05g08800 | intergenic_region ; MODIFIER | silent_mutation | Average:75.981; most accessible tissue: Callus, score: 87.204 | N | N | N | N |
| vg0504837001 | CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA -> C | LOC_Os05g08790.1 | upstream_gene_variant ; 1353.0bp to feature; MODIFIER | N | Average:75.981; most accessible tissue: Callus, score: 87.204 | N | N | N | N |
| vg0504837001 | CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA -> C | LOC_Os05g08800.1 | downstream_gene_variant ; 554.0bp to feature; MODIFIER | N | Average:75.981; most accessible tissue: Callus, score: 87.204 | N | N | N | N |
| vg0504837001 | CGAATGCAGGAAAATCACAATTTCCTTTATAAAGAGTTAACAAAATTGTCTAGTGAAACAAATGTTAACAAA -> C | LOC_Os05g08790-LOC_Os05g08800 | intergenic_region ; MODIFIER | N | Average:75.981; most accessible tissue: Callus, score: 87.204 | N | N | N | N |
For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.
| Var ID | Ref | Alt | Root (RT) | Young Leaf (YL) | Flag Leaf (FL) | Young Panicle (YP) | Lemma & Palea (LP) | Stamen & Pistil (SP) |
|---|---|---|---|---|---|---|---|---|
| vg0504837001 | CGAAT* | AGAAT* | 0.01 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| vg0504837001 | CGAAT* | C | 0.44 | 0.58 | 0.36 | 0.32 | 0.25 | 0.32 |
| Var ID | LMM P-value | LR P-value | Trait | Subpopulation | Is leadSNP | Publication |
|---|---|---|---|---|---|---|
| vg0504837001 | NA | 1.24E-12 | Grain_thickness | Ind_All | Not | Breeding signatures of rice improvement revealed by a genomic variation map from a large germplasm collection, Proc Natl Acad Sci USA, 112(39): E5411-E5419, PMID:26358652 |
| vg0504837001 | 2.35E-06 | NA | Grain_width | All | Not | Breeding signatures of rice improvement revealed by a genomic variation map from a large germplasm collection, Proc Natl Acad Sci USA, 112(39): E5411-E5419, PMID:26358652 |
| vg0504837001 | 4.32E-08 | 3.26E-23 | Grain_width | Ind_All | Not | Breeding signatures of rice improvement revealed by a genomic variation map from a large germplasm collection, Proc Natl Acad Sci USA, 112(39): E5411-E5419, PMID:26358652 |
| vg0504837001 | NA | 6.41E-06 | mr1113 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 3.89E-06 | mr1114 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 2.89E-07 | mr1319 | All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 9.36E-06 | mr1319 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 1.49E-06 | mr1330 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 5.10E-09 | mr1332 | All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 2.43E-06 | mr1392 | All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 9.21E-06 | mr1424 | All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 3.02E-08 | mr1438 | All | YES | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 5.56E-06 | mr1639 | Jap_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 1.43E-06 | mr1735 | All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 7.94E-09 | mr1794 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 1.51E-06 | mr1319_2 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 1.52E-07 | mr1330_2 | Ind_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |
| vg0504837001 | NA | 2.41E-06 | mr1546_2 | Jap_All | Not | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251 |