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Detailed information for vg0400775321:

Variant ID: vg0400775321 (JBrowse)	Variation Type: SNP
Chromosome: chr04	Position: 775321
Reference Allele: T	Alternative Allele: C
Primary Allele: T	Secondary Allele: C

Inferred Ancestral Allele: Not determined.

Flanking Sequence (100 bp) in Reference Genome:

GATGAACCCCTGATGGCCTCCACTGCATACATCTGGTCCAACACCCTCAACGCCTTCATGTTCAACCAAGGGCAGATGACCCCCACTTTGCTAGACATCA[T/C]
CATGATTACTGGCCTAGACATCTCAGCATCGGCCAACCCTATGAACTTGAACTCCAAGAATCAGTTTGAGTTCAAAACCAAAACCATAGGTGGCTGGTCC

Reverse complement sequence

GGACCAGCCACCTATGGTTTTGGTTTTGAACTCAAACTGATTCTTGGAGTTCAAGTTCATAGGGTTGGCCGATGCTGAGATGTCTAGGCCAGTAATCATG[A/G]
TGATGTCTAGCAAAGTGGGGGTCATCTGCCCTTGGTTGAACATGAAGGCGTTGAGGGTGTTGGACCAGATGTATGCAGTGGAGGCCATCAGGGGTTCATC

Allele Frequencies:

Populations	Population Size	Frequency of T(primary allele)	Frequency of C(secondary allele)	Frequency of N	Frequency of DEL	Frequency of others Allele
All	4726	37.50%	0.30%	5.56%	56.67%	NA
All Indica	2759	10.00%	0.50%	9.13%	80.32%	NA
All Japonica	1512	77.00%	0.00%	0.40%	22.62%	NA
Aus	269	78.10%	0.00%	0.00%	21.93%	NA
Indica I	595	6.90%	0.30%	5.55%	87.23%	NA
Indica II	465	10.80%	0.40%	9.89%	78.92%	NA
Indica III	913	10.40%	0.90%	12.16%	76.56%	NA
Indica Intermediate	786	11.60%	0.30%	7.89%	80.28%	NA
Temperate Japonica	767	75.90%	0.00%	0.13%	23.99%	NA
Tropical Japonica	504	81.00%	0.00%	0.40%	18.65%	NA
Japonica Intermediate	241	72.20%	0.00%	1.24%	26.56%	NA
VI/Aromatic	96	71.90%	0.00%	3.12%	25.00%	NA
Intermediate	90	56.70%	0.00%	2.22%	41.11%	NA

Allele Effect:

Var ID	Var	Locus	snpEff Annotation	CooVar Annotation	Chromatin Accessibility Score	PolyPhen-2 Effect	PolyPhen-2 Score	SIFT Effect	SIFT Score
vg0400775321	T -> C	LOC_Os04g02230.1	upstream_gene_variant ; 4568.0bp to feature; MODIFIER	silent_mutation	Average:65.139; most accessible tissue: Minghui63 young leaf, score: 90.357	N	N	N	N
vg0400775321	T -> C	LOC_Os04g02250.1	downstream_gene_variant ; 3477.0bp to feature; MODIFIER	silent_mutation	Average:65.139; most accessible tissue: Minghui63 young leaf, score: 90.357	N	N	N	N
vg0400775321	T -> C	LOC_Os04g02240.1	intron_variant ; MODIFIER	silent_mutation	Average:65.139; most accessible tissue: Minghui63 young leaf, score: 90.357	N	N	N	N
vg0400775321	T -> DEL	N	N	silent_mutation	Average:65.139; most accessible tissue: Minghui63 young leaf, score: 90.357	N	N	N	N

Effects Predicted by Deep Convolutional Neural Networks

For each variant, we constructed two sequences that contain the variation site and the sequence around it, differing only in the variation site. We then used Basenji to predict the chromatin accessibility of each tissue for the two sequences, respectively, and scored the effect of the variant by comparing the changes in chromatin accessibility corresponding to the two genotypes in the 1 kb region around the variation site. The effect score was defined as the logarithmic ratio of the predicted chromatin accessibility of the alternative genotype to the value of the reference genotype.

Var ID	Ref	Alt	Root (RT)	Young Leaf (YL)	Flag Leaf (FL)	Young Panicle (YP)	Lemma & Palea (LP)	Stamen & Pistil (SP)
vg0400775321	T	C	0.01	0.01	0.0	0.0	0.01	0.0

Putative Genotype-Phenotype Associations:

Var ID	LMM P-value	LR P-value	Trait	Subpopulation	Is leadSNP	Publication
vg0400775321	NA	2.28E-07	mr1058	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0400775321	NA	2.06E-08	mr1398	All	YES	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0400775321	NA	6.01E-06	mr1468	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251
vg0400775321	NA	3.32E-06	mr1966_2	All	Not	Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism, Nat Genet, 46(7):714-21, PMID:24908251